A comprehensive review published by Lubert Stryer in 1978 entitled Fluorescence energy transfer as a spectroscopic ruler provided a description of the Frsters theory and of the experimental tests of its validity, systemized experimental strategy for the measurements of transfer efficiency, and summarized data on using energy transfer for elucidation of the proximity relationships in a wide variety of biological macromolecules and assemblies, and thereby represented FRET as a powerful tool in the analysis of protein structure and interactions (Stryer, 1978)
Targeting autophagy in ischemic stroke: from molecular mechanisms to clinical therapeutics
Beneficial Effects of Combined Resveratrol and Metformin Therapy in Treating Diet-Induced Insulin Resistance
The study by Liu et al
Talk to your clinician if you have heart disease, seizure risk, or kidney disease
An in vivo experiment based on the acute HH mouse model has confirmed that prophylactic administration of tetrahydrocurcumin can alleviate acute HH-induced brain edema, reduce the levels of inflammatory factors IL-1 and TNF-, increase SOD activity to enhance hypoxia resistance, and inhibit the NF-B/VEGF/MMP-9 pathway to reduce HH-induced brain edema and inflammation, thereby exerting neuroprotective effects ( Curcuma longa and its active metabolites, through multi-target regulation of inflammatory responses and BBB protection, may provide a novel strategy for the pathological intervention of brain edema in hypoxic environments at high altitudes
